《生命科学》 2016, 28(7): 817-823

细菌性疾病的新疗法——噬菌体疗法

郭婷婷，李　玲*，孙元章，陈玉春，谷　巍

(山东宝来利来生物工程股份有限公司生物研究院，泰安 271000)

摘　要：摘　要：在败血症等一些严重细菌性疾病的防治上，传统的抗生素法出现了越来越严重的细菌耐药性、残留等问题，因此，噬菌体疗法等一些非抗疗法日渐受到人们的广泛关注。现对噬菌体分类和生物学特征，以及国内外利用噬菌体防治动物和人类细菌感染疾病的临床试验结果进行阐述和评价，并分析噬菌体疗法的优缺点。噬菌体疗法表现出许多抗生素法无法比拟的优势，是一种非常有发展前景的替代抗生素治疗的新方法。

The new therapy of bacteria infection: bacteriophage therapy

GUO Ting-Ting， LI Ling*， SUN Yuan-Zhang， CHEN Yu-Chun， GU Wei

(Biological Research Institute， Shandong Baolai-Leelai Bio-engineering Co.， Ltd， Tai’an 271000， China)

Abstract: Abstract: In the prevention of sepsis and some other severe bacterial diseases， the traditional antibiotic therapy appeared more and more serious bacterial resistance， antibiotic residues and other problems， therefore phage therapy and some other non-anti therapies have received widespread attention. Here we elucidate and evaluate the classification and biological characteristics of phages， the clinical results of the application of phage in the treatment of animal and human bacterial infections， and also analyze the advantages and disadvantages of phage therapy. Phage therapy has shown many incomparable advantages， which is a promising alternative to antibiotics for bacterial pathogens.