《生命科学》 2016, 28(7): 777-780

肝再生磷酸酶-2的最新研究进展

殷岑楠，吴琛耘，王兆军*

(上海交通大学医学院免疫学与微生物学系，感染免疫实验室，上海 200025)

摘　要：摘　要：肝再生磷酸酶-2 (phosphatase of regenerating liver-2， PRL-2) 是蛋白酪氨酸磷酸酶家族的成员。作为一种蛋白磷酸酶，PRL 家族因其成员PRL-3 在肿瘤组织中的特异性高表达而备受人们关注。在近几年的研究中，人们逐渐把目光转向了在正常人体各个组织中均高表达的PRL-2 分子，现综述了PRL-2 的生物学功能及其在肿瘤相关研究中的最新进展。

The latest research progress in PRL-2

YIN Cen-Nan， WU Chen-Yun， WANG Zhao-Jun*

(Laboratory of Infection and Immunology， Department of Immunology and Microbiology， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract: Abstract: Phosphatase of regenerating liver-2 (PRL-2) is a member of protein tyrosine phosphatases family. As a protein phosphatase， PRL-3， the third member of PRL family， has attracted much interest due to its specific high expression in tumor tissues. However， as PRL-2 is widely expressed in normal adult tissues， researchers have become more and more interested in PRL-2. Here， we provide an overview of the physcial function of PRL-2 and its role in cancer.