《生命科学》 2016, 28(7): 766-770

Trps1参与上皮细胞间质转化的分子机制

汪晓玲，黄利鸣，王艳林*

(三峡大学医学院肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002)

摘　要：摘　要：上皮细胞间质转化(EMT) 是上皮细胞在特定条件下向间充质细胞转分化的过程，该过程受到多种信号分子的调节和控制。最新研究表明，GATA 样转录因子Trps1 能靶向调节EMT 相关基因，如FOXA1、ZEB2、Pax2、Wt1、Arkadia 等的表达，在维持上皮细胞表型和抑制EMT 中发挥关键作用。同时，Trps1的表达也受到miRNA 的调控。对Trps1 调控EMT 作用机制的深入研究，将为相关疾病治疗提供新的分子靶点和新的治疗策略。现就Trsp1 与EMT 相互关系的研究进展作一综述。

The mechanism of Trps1 induced epithelial-mesenchymal transition

WANG Xiao-Ling， HUANG Li-Ming， WANG Yan-Lin*

(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， Medical College， Three Gorges University， Yichang 443002， China)

Abstract: Abstract: The epithelial-mesenchymal transition (EMT) is a highly conserved cellular process in which epithelial cells are converted into mesenchymal cells in specific conditions and this process is regulated by various signal molecules. Recent researches indicate that Trps1， a GATA-like transcription factor， plays a key role in maintaining epithelial phenotype and inhibiting EMT through regulating expression of multiple EMT-related genes， such as FOXA1， ZEB2， Pax2， Wt1 and Arkadia. In addition， Trps1 is also regulated by miRNAs in the process of EMT. This paper reviews the research progress about relationship between Trsp1 and EMT.