《生命科学》 2016, 28(6): 718-725
摘 要：摘 要：MicroRNAs (miRs) 是一类非编码单链RNA，可介导靶mRNA 降解或抑制靶mRNA 翻译，从而调节靶基因的表达，在生理和病理过程中发挥重要作用。目前miRs 已被证实与肾脏及肾脏疾病密切相关，并参与了肾纤维化的发生、发展及预后，其中以miR-21、miR-192、miR-29、miR-200 的研究最为深入。现就近年来miRs 在肾纤维化中的功能研究进展做一综述，并为今后肾纤维化的诊断、治疗提供参考。
Abstract: Abstract: MicroRNAs (miRs) are short noncoding single stranded RNAs that mediate target mRNA degradation or inhibit target mRNA translation， and play an important role in physiological and pathological processes. MiRs have been found to be functionally important in renal physiology and pathology， and are involved in the genesis， growth and prognosis of renal fibrosis， especially miR-21， miR-192， miR-29 and miR-200. The purpose of this review is to highlight the roles of key miRNAs in the pathogenesis of renal fibrosis.
