《生命科学》 2016, 28(6): 686-694

非编码RNA在近日节律中的作用

后　望，杨淑红，王正荣*，应俊杰，杨振华，徐　涛，丁　璐，汪宇辉，江　舟，成姝婷

(四川大学卫生部时间生物学重点实验室，四川大学华西基础医学与法医学院生物医学工程研究室，成都 610041)

摘　要：摘　要：生物节律系统作为生物体的基本系统之一在稳态维持、新陈代谢、睡眠与觉醒和癌症的发生与治疗等生理及病理领域发挥了重要影响。而针对节律调节机制本身的研究也是生物研究的热点领域之一。作为生物研究的“新大陆”，非编码RNA (ncRNA) 与节律系统和核心节律基因的相互作用日益为人所重视，已成为时间生物学领域最具潜力的研究课题之一。将综合国内外对非编码RNA 与生物钟相互作用的研究现状，对参与其中的非编码RNA 成员和机制做逐一综述。

The function of non-coding RNA in circadian rhythm system

HOU Wang， YANG Shu-Hong，WANG Zheng-Rong*， YING Jun-Jie， YANG Zhen-Hua， XU Tao， DING Lu， WANG Yu-Hui， JIANG Zhou， CHENG Shu-Ting

(Health Ministry Key Laboratory of Chronobiology， Sichuan University， Pre-clinic and Forensic Medical School， Sichuan University， Chengdu 610041， China)

Abstract: Abstract: Circadian rhythm system affect a variety of physiological and phathological processes like homeostasis， metabolism， sleep-wake and the occurrence and treatment of cancer. Futhermore， the regulatory mechanisms for the circadian rhythm are one of the hottest areas in biological research. As a new world of biological research， the relationship between the non-coding RNA (ncRNA) and circadian rhythm system has become one of the most promising research projects in the field of chronobiology. In this review， we will summarize our current knowledge about the interaction between the ncRNA and circadian rhythm system， then pay close attention to the members of ncRNA and the mechanisms in this field.