《生命科学》 2016, 28(6): 671-679

长非编码RNA与肿瘤代谢

朱友明1*，吴　缅2*

(1 安徽医科大学口腔医学院，安徽口腔疾病研究重点实验室，合肥 230032；2 中国科学技术大学生命科学学院，中国科学院分子细胞科学卓越创新中心，细胞信号网络协同创新中心，中国科学院天然免疫和慢性疾病重点实验室，合肥 230027)

摘　要：摘　要：长链非编码RNA (1ong noncoding RNA， lncRNA) 通过对基因的表达调控及形成蛋白质复合体等多种机制，广泛地参与细胞的增殖、分化、凋亡、迁移、衰老及代谢等各种生命过程，其表达与机体的正常发育以及人类的重大疾病发生密切相关。对近年来lncRNA 与细胞代谢，主要是糖代谢和脂代谢的最新进展作一简要综述。

Long noncoding RNA and tumor metabolism

ZHU You-Ming1*， WU Mian2*

(1 Key Laboratory of Oral Diseases Research of Anhui Province Hefei， Department of Dental Implant Center， Stomatologic Hospital and College， Anhui Medical University， Hefei 230032， China; 2 CAS Key Laboratory of Innate Immunity and Chronic Disease， CAS Center for Excellence in Molecular Cell Science， Innovation Center for Cell Signaling Network， School of Life Sciences， University of Science & Technology of China， Hefei 230027， China)

Abstract: Abstract: Long noncoding RNA is a new type of molecules which are widely involved in key biological processes related to cell proliferation， differentiation， cell death/migration， cell aging and metabolism. It regulates gene expression at different levels by interaction with various DNA， RNA or proteins and thus to affect normal physiology and human disease. In this short review， we will focus on the most recent development on the lncRNAs in regulating glucose and lipid metabolism for tumor cells.