《生命科学》 2016, 28(6): 663-670

长链非编码RNA调控肿瘤转移的研究进展

王会丽1，2，王　栋1，2*

(1 清华大学医学院基础医学系，北京 100084；2 清华大学生物治疗协同创新中心，北京 100084)

摘　要：摘　要：长链非编码RNA (long non-coding RNA， lncRNA) 是指转录本长度大于200 个核苷酸，不具备蛋白质编码功能的一类RNA。以往人们认为，非编码RNA 是“垃圾产物”，但最近研究发现，长链非编码RNA 参与调控多项重要的生命过程，其中包括肿瘤转移。肿瘤是影响人类健康的重大恶性疾病，但实际上90% 的肿瘤患者并不是死于原发癌，而是死于肿瘤转移。因此，探究肿瘤转移调控的分子机制，无论是对了解生命调控本质还是对肿瘤患者的临床诊治都具有重大意义。对近几年来lncRNA 参与肿瘤转移过程的研究进展进行综述，希望能帮助发现更多对肿瘤转移具有重要调控作用的长链非编码RNA。

Long non-coding RNAs in tumor metastasis

WANG Hui-Li1，2， WANG Dong1，2*

(1 Department of Basic Medical Sciences， School of Medicine， Tsinghua University， Beijing 100084， China; 2 Collaborative Innovation Center for Biotherapy， Tsinghua University， Beijing 100084， China)

Abstract: Abstract: Long noncoding RNAs are transcripts longer than 200 nt with no protein-coding potential. In the past decades， they have been regarded as “junk gene”. However， recent studies indicate long noncoding RNAs participate in a wide repertoire of biological processes including tumor metastasis. Cancer is still a major health problem and about 90% of cancer patients die of metastatic tumor instead of primary tu+-mor. Revealing the mechanism of tumor metastasis is crucial for understanding the nature of biology regulation as well as cancer treatment. Here， we summarize the recent research discoveries of roles of long noncoding RNAs in tumor metastasis， and wish this review might facilitate to disclose more long noncoding RNAs involved in the process of tumor progression.