《生命科学》 2016, 28(5): 569-575

非编码RNA对基因转录的调控

刘　旭，单　革*

(中国科学技术大学生命科学学院，合肥 230026)

摘　要：摘　要：非编码RNA 是各种不作为翻译蛋白质的模板的RNA 的统称，参与很多生命活动的调控并扮演着重要的角色。它们参与mRNA 翻译、RNA 剪切、化学反应催化，以及参与DNA 复制修复、基因转录调控、发育和细胞分化调控等。现针对哺乳动物细胞内非编码RNA 调控依赖于RNA 聚合酶II，产物为mRNA 的转录进行综述。

Regulation of gene transcription by non-coding RNAs

LIU Xu， SHAN Ge*

( School of Life Science， University of Science and Technology of China， Hefei 230026， China )

Abstract: Abstract: Non-coding RNAs (ncRNAs) are RNA molecules that do not serve as template for translation. They participate in a myriad of biological processes and play crucial regulatory roles. NcRNAs have been found to regulate translation and splicing， serve as ribozymes， modulate DNA replication and gene transcription， dictate development and cell differentiation. In this review， we focus on the regulation of ncRNAs in the transcription of RNA polymerase II in mammalian cells.