《生命科学》 2016, 28(4): 521-527

胶原支架在骨髓间充质干细胞治疗中枢神经系统疾病中的应用

高　月#，储成艳#，李　深*

(大连医科大学附属大连市中心医院神经内科，大连 116033)

摘　要：摘　要：骨髓间充质干细胞(bone marrow-derived mesenchymal stem cells， BMSCs) 已被证明能够改善中枢神经系统疾病的预后，但单独移植的BMSCs 很难在损伤部位长期存活并分化为神经细胞。新近研究发现，胶原支架能够促进BMSCs 的增殖、存活与分化，进而增强其修复缺损组织、重建神经功能的作用。现就BMSCs 治疗中枢神经系统疾病的研究现状、胶原支架的应用和改性方式及其复合BMSCs 治疗中枢神经系统疾病的研究进展进行综述。

Role of collagen scaffold in facilitating the therapeutic effect of bone mesenchymal stem cells for central nervous system diseases

GAO Yue#， CHU Cheng-Yan#， LI Shen*

(Department of Neurology， Dalian Municipal Central Hospital Affilicated to Dalian Medical University， Dalian 116033， China)

Abstract: Abstract: BMSCs (bone marrow-derived mesenchymal stem cells， BMSCs) have been proven to improve the prognosis of various central nervous system diseases. However， they could barely achieve long-term survival and neural differentiation in the lesion sites when they were transplanted alone. Recent studies have shown that collagen scaffold is capable of enhancing the proliferation， survival and differentiation of BMSCs， which in turn strengthens
    the effect of BMSCs in repairing damaged tissue and reconstructing nervous function. The purpose of this review is to summarize the current progress of BMSCs in treatment of central nervous system diseases， the application of collagen and its modification as biomaterial， as well as the combination of BMSCs and collagen scaffold on treatment of central nervous system diseases.