《生命科学》 2016, 28(4): 486-492

β-淀粉样前体蛋白基因表达及加工调控的研究进展

武雪玲，常　平，姜招峰，劳凤学，黄汉昌*

(北京联合大学功能食品科学技术研究院，生物活性物质与功能食品北京市重点实验室，北京 100191)

摘　要：摘　要：β- 淀粉样蛋白(amyloid-β， Aβ) 是阿尔茨海默病(Alzheimer's disease， AD) 形成和发展的关键因素，而Aβ 的过量产生则来源于β- 淀粉样前体蛋白(amyloid precursor protein， APP) 的异常裂解。因此，导致APP 基因表达失控或异常剪切的因素在AD 的发病中起着重要作用。目前的研究多数侧重于通过减少已经产生的Aβ 来治疗AD，但很少从APP 基因表达水平的角度来抑制Aβ 产生，从而寻找解决方法。现就影响Aβ 生成的因素及APP 基因表达及代谢调控的作用机制做一综述，以期为未来 AD 的治疗提供更多的理论基础。

Research progress on regulations of APP gene expression and processing

WU Xue-Ling， CHANG Ping， JIANG Zhao-Feng， LAO Feng-Xue， HUANG Han-Chang*

(Beijing Key Laboratory of Bioactive Substances and Functional Food， College of Arts and Science， Beijing Union University， Beijing 100191， China)

Abstract: Abstract: Amyloid-β (Aβ) is a key factor in the onset and development of the Alzheimer's disease (AD)， and the abnormal cleavage of amyloid precursor protein (APP) attributes to the overproduction of Aβ. Therefore， the factors
    resulting in uncontrollable expression of APP gene or abnormal processing of this protein play an important role in the pathogenesis of AD. Most of studies have focused on AD treatment by reducing the level of generated Aβ rather than by suppressing Aβ generation. This article summarizes the factors affecting Aβ generation and the mechanism on APP gene regulation in order to provide more theoretical basis in AD treatment.