《生命科学》 2016, 28(4): 480-485

G-CSF动员造血干细胞机制研究进展

李程程，孟爱民*

(中国医学科学院医学实验动物学研究所，北京 100021)

摘　要：摘　要：人类粒细胞集落刺激因子(granulocyte colony-stimulating factor， G-CSF) 是临床上广泛应用的细胞因子之一，最早用于治疗中性粒细胞减少症，降低癌症患者化疗后的死亡率。在临床应用中发现，其可以有效地动员骨髓中造血干细胞进入外周血，目前是临床上最常用的造血干细胞动员剂。介绍了G-CSF 的生物学特性，并详细阐述了G-CSF 动员造血干细胞的机制，为临床上G-CSF 提高动员效率、减少副作用，以及为新型造血干细胞动员剂的开发提供理论基础。

Research progress on the hematopoietic stem cell mobilization mechanism of G-CSF

LI Cheng-Cheng， MENG Ai-Min*

(Institute of Laboratory Animal Sciences， Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)， Beijing 100021， China)

Abstract: Abstract: G-CSF has been widely used in clinical， and it is not only used to treat neutropenia， but also used to reduce the mortality of cancer patients after chemotherapy. What’s more， G-CSF is the most widely used hematopoietic stem cell (HSC) mobilization agent at present. The review introduced the biology of G-CSF， and focused on the HSC mobilization mechanism of G-CSF. To explore the exact mechanism is necessary to improve the efficiency of G-CSF mobilization， and to provide a theoretical basis for the development of new hematopoietic stem cell mobilization agents in the future.