《生命科学》 2016, 28(3): 409-414

PM2.5对线粒体损伤作用机制的研究进展

毕婷婷，陈世杰，赵晓红*，周艳丽，劳文艳

(北京联合大学功能食品科学技术研究院，北京 100191)

摘　要：摘　要：线粒体是生命体能量和ROS 的主要来源，对细胞的存活与死亡具有十分重要的调控作用，且是容易受到外界刺激的重要靶标。PM2.5 对线粒体的毒性损伤机制可能与线粒体通透性转换孔开放、线粒体动力学异常等机制相关，在环境医学领域得到广泛研究。因此，希望通过对线粒体的结构与特点以及PM2.5 诱导线粒体损伤的机制进行综述，为进一步研究PM2.5 的毒性作用机制提供科学依据。

Advances on mechanism of mitochondrial damage induced by PM2.5

BI Ting-Ting， CHEN Shi-Jie， ZHAO Xiao-Hong*， ZHOU Yan-Li， LAO Wen-Yan

(Research Institute for Science and Technology of Functional Food， Beijing Union University， Beijing 100191， China)

Abstract: Abstract: Mitochondria are the major sources of cellular energy and reactive oxygen species (ROS)， which play fundamental roles in regulation of cell survival and death. Mitochondria are also the important targets vulnerable to external stimulations. It is known that the damage effects of PM2.5 on mitochondria might be related to the opening of mitochondrial permeability transition pore and the unbalance of mitochondrial dynamics， which have been widely studied in the field of environment and medicine. Therefore， the mechanism of mitochondrial damage induced by PM2.5 is reviewed to provide scientific data for the further research on mechanisms of PM2.5 toxicity.