《生命科学》 2016, 28(3): 405-408

NALP3炎性体在痛风发病中的作用与药物治疗研究进展

王　璐，李　璐，陈光亮*

(安徽中医药大学中西医结合临床学院，合肥 230038)

摘　要：摘　要：痛风是体内嘌呤代谢紊乱引起尿酸钠盐沉积所致的晶体相关性疾病。近年研究表明，核苷酸结合寡聚化结构域样受体3 (nucleotide-binding oligomerization domain-like receptor protein 3， NALP3) 炎性体活化与巨噬细胞吞噬尿酸钠晶体密切相关。NALP3 炎性体活化后可剪切半胱天冬酶-1 并促进白介素1β 释放，引起痛风炎症反应。现将从NALP3 炎性体的组成及活化、尿酸钠晶体的吞噬识别途径，以及以NALP3 炎性体为靶点的抗痛风药物等方面作一综述。

Role of NALP3 inflammasome in the pathogenesis of gout and advances in drug treatment

WANG Lu， LI Lu， CHEN Guang-Liang*

(Clinical College of Integrative Medicine， Anhui University of Chinese Medicine， Hefei 230038， China)

Abstract: Abstract: Gout is a kind of inflammation caused by purine metabolism disturbance and deposits of monosodium urate (MSU) crystals. Nucleotide-binding oligomerization domain-like receptor protein 3 (NALP3) inflammasome is a protein complex which can be activated by MSU crystal when the crystal is swallowed by macrophage， then leading to gout inflammation reaction by cleaving caspase-1 to produce and release interleukin-1β. The activation and composition of NALP3 inflammasome， the identification of MSU crystal in the pathogenesis of gout， and the drugs targeting NALP3 inflammasome were summarized in this article.