《生命科学》 2016, 28(3): 399-404

鸟氨酸脱羧酶抗酶抑制因子-1与细胞增殖

吕亚丰，王艳林*

(三峡大学医学院，肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002)

摘　要：摘　要：多胺( 腐胺、精脒、精胺) 参与细胞增殖、分化和凋亡等重要生命过程，细胞内多胺代谢紊乱也与包括肿瘤在内的多种疾病的发生发展密切相关。鸟氨酸脱羧酶抗酶抑制因子-1 (antizyme inhibitor-1，AZIN1) 是重要的多胺代谢调节蛋白，它通过多种途径调控细胞的生长。AZIN1 能与鸟氨酸脱羧酶抗酶(antizyme， AZ) 相互作用，解除后者对多胺合成限速酶鸟氨酸脱羧酶(ornithine decarboxylase， ODC) 的抑制，由此上调细胞内多胺的含量。AZIN1 还能通过调节细胞周期蛋白cyclin D1 的降解速度和干扰细胞中心体复制而影响细胞增殖。AZIN1 基因转录后修饰和某些特定miRNA 也对AZIN1 的细胞增殖调节功能有重要影响。现对该研究领域的研究进展做简要综述。

Ornithine decarboxylase antizyme inhibition factor 1 and cell proliferation

LV Ya-Feng， WANG Yan-Lin*

(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， Three Gorges University Medical College， Yichang 443002， China)

Abstract: Abstract: Polyamines (putrescine， spermidine， spermine) is involved in many important life processes including cell proliferation， differentiation and apoptosis. Intracellular metabolic disorder of polyamines is closely related to the occurrence and development of some diseases， such as tumor. Ornithine decarboxylase antizyme inhibitor-1 (AZIN1) is an important regulatory protein for polyamine metabolism which affects cell proliferation through a variety of ways. AZIN1 can interact with ornithine decarboxylase antizyme (AZ) that will relieve AZ’s inhibition on ornithine decarboxylase (ODC)， a rate-limiting enzyme in polyamine synthesis， and thus up-regulate polyamine content within cells. AZIN1 can also affect cell proliferation by regulating degradation of cyclin D1 and interfering centrosome duplication. Post transcriptional modification of AZIN1 gene and some specific miRNA have important effects on the function of AZIN1 in regulating cell proliferation also. This paper briefly reviews the progress in this research field.