《生命科学》 2006, 18(3):

“Click”化学在药物发现中的应用

仇文卫，李静雅，李　佳^*，南发俊^*

中国科学院上海生命科学研究院药物研究所，国家新药筛选中心，上海 201203

摘　要：摘　要：“click”化学是最近几年发展起来的一种新技术，它在药物发现的许多方面均有着广泛的应用：快速合成小分子化合物库并从中筛选先导化合物、进行靶标导向的活性小分子合成以及在生物耦联技术等方面的应用。
关键词：“click”化学；组合化学；靶标导向合成；生物耦联技术；药物发现

Click chemistry in drug discovery

QIU Wen-Wei, LI Jing-Ya, LI Jia^*, NAN Fa Jun^*

The National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China

Abstract: Abstract: The click chemistry is a new technology that developed in recent years, it has many applications in fields of drug discovery, including construction of focused libraries in microtiter plate and screened straight, target-guided synthesis of high-affinity inhibitors, and in bioconjugate chemistry.
Key words: click chemistry; combinatorial chemistry; target-guided synthesis; bioconjugate chemistry; drug discovery