《生命科学》 2016, 28(2): 239-247

细胞微环境对免疫细胞黏附与迁移的调控

张海龙，路　玲，郑雅娟，袁萌芽，陈剑峰*

(中国科学院上海生命科学研究院，生物化学与细胞生物学研究所，细胞生物学国家重点实验室，上海 200031)

摘　要：摘　要：免疫细胞的黏附与迁移是机体免疫与宿主防御的关键环节，在机体免疫监视以及稳态维持中发挥重要作用，甚至参与到癌细胞转移的过程中。免疫细胞在血管内皮表面的滚动、活化、稳定黏附和定向迁移依赖整合素功能，并受到细胞微环境，包括生物微环境、化学微环境以及物理微环境的多因子协同作用和调控。细胞微环境的紊乱往往导致免疫细胞黏附与迁移的异常，引发炎症性疾病，甚至肿瘤。将对细胞微环境通过整合素调控免疫细胞黏附与迁移进行概述，重点介绍生物微环境、化学微环境和物理微环境对免疫细胞黏附与迁移的调控机制。

Regulation of immune cell adhesion and migration by cell microenvironments

ZHANG Hai-Long， LU Ling， ZHENG Ya-Juan， YUAN Meng-Ya， CHEN Jian-Feng*

(State Key Laboratory of Cell Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Immunocytes adhesion and migration are critical for immune response and homeostasis， and play important roles in immune surveillance， host defence and even cancer metastasis. Immunocyte homing requires a cascade of four distinct molecular steps: immunocyte rolling， activation， firm adhesion and migration on endothelium. These steps reply on integrin functions that are regulated by cell microenvironments including biological， chemical and physical microenvironments. The dysregulation of cell microenvironments triggers aberrant immunocyte adhesion and migration， resulting in inflammatory diseases and even cancer. In this review， we aim to discuss the role of cell microenvironments in regulating immunocyte adhesion， migration and its underlying mechanism.