《生命科学》 2006, 18(3):

一种新的疾病治疗候选基因: SOCS-1

崔　强^1,2，蔡　荣²，钱　程²，魏　萍^1*

1东北农业大学动物医学学院，哈尔滨150030；2浙江理工大学生命科学学院新元医学与生物技术研究所，杭州310018

摘　要：摘　要：SOCS(suppressor of cytokine signalling)是细胞因子信号传导通路JAK/STAT(janus kinase/signal transduction and activators of transcription)的一个负性调控分子家族。近年来很多研究表明，SOCS在癌症、糖尿病、自身免疫性疾病和炎症等多种疾病的发生发展过程中及在机体免疫调节中发挥着重要的作用，该蛋白分子家族的成员可能会成为重大疾病治疗的一种新候选基因。
关键词：细胞因子信号传导抑制因子-1；Janus激酶；信号转导及转录激活子

SOCS-1: a new candidate for major disease therapy

CUI Qiang^1,2, CAI Rong², QIAN Cheng², WEI Ping^1*

1 Veterinary Medicine College , Northeast Agriculture University, Haerbin 150030, China; 2 Xin-Yuan Institute of Medicine and Biotechnology, Zhejiang Science &Technology University, Hangzhou 310018, China

Abstract: Abstract: SOCS (suppressor of cytokine signaling) family is a kind of  protein molecular responsible for negative regulations on JAK/STAT signaling transduction. Recently, it has been observed that SOCS is involved in cancer, diabetes and inflammation and plays an important role in immune regulations in vivo. It suggests that maybe SOCS will become a new candidate for major disease therapy.
Key words: SOCS-1; JAK; STAT