《生命科学》 2016, 28(2): 137-145

抗原非特异性T细胞对天然免疫炎性反应的调控

陈海荣1，张　超1，张胜源1，王为红1，李舒然1，唐　宏1，2*

(1 中国科学院生物物理研究所感染与免疫重点实验室，北京 100101；2 中国科学院上海巴斯德研究所，上海 200031)

摘　要：摘　要：天然免疫是抵御微生物入侵的第一道防线，其稳态的建立与维持须受到精确调控。近期研究进展表明，传统意义上抗原特异性免疫细胞——T 细胞，能够以抗原非特异的方式在天然免疫阶段调节炎性反应，并决定了机体对微生物的免疫应答稳态。因此，深入了解T 细胞以及不同T 细胞亚型对天然免疫炎性反应的调控机制，有助于绘制天然免疫新的调控网络，阐述炎性疾病的发病机制，并提供新的治疗策略。

Regulation of innate inflammation by antigen non-specific T cells

CHEN Hai-Rong1， ZHANG Chao1， ZHANG Sheng-Yuan1， WANG Wei-Hong1， LI Shu-Ran1， TANG Hong1，2*

(1 Key Laboratory of Infection and Immunity， Institute of Biophysics， Chinese Academy of Sciences， Beijing 100101， China; 2 Institut Pasteur of Shanghai， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Innate immune response is the first line of defence against invaded pathogens， thus a precise regulation is required to establish and maintain such an innate homeostasis. Emerging evidence has shown that T cells， conventionally functioning in an antigen-specific manner， retains the capability of pathogenic antigen non-specific response， which fundamentally determines the outcome of innate inflammatory response to pathogen infections. Therefore， a better understanding of the mechanisms of how T cells respond and regulate innate inflammation helps to draw a novel regulatory network for innate-immunity， and provide a new dimension to understand the immune pathogenesis and immune intervention against infections.