《生命科学》 2016, 28(1): 44-50

黄曲霉毒素生物合成代谢相关的基因组信息挖掘和转录调控因子研究进展

支庆庆，李洁莹，于　雷，贺竹梅*

(中山大学生命科学学院水产品安全教育部重点实验室，广州 510275)

摘　要：摘　要：黄曲霉毒素生物合成调控机制的研究已成为研究真核生物次级代谢过程的模式系统，真菌基因组学及其他组学技术的快速发展为我们挖掘基因组信息、获取基因表达谱继而为黄曲霉毒素生物合成调控网络及其他真菌次级代谢机制的研究提供基础。真菌次级代谢基因的表达需要不同类型的转录因子进行调控，包括通路特异性转录因子、全局性转录因子及应答各种环境信号的广泛转录因子等，对这些转录因子功能的研究加快了对黄曲霉毒素生物合成代谢调控机制的认识。

Genome mining and transcription regulatory factors research in aflatoxin biosynthesis

ZHI Qing-Qing， Li Jie-Ying， YU Lei， HE Zhu-Mei*

(MOE Key Laboratory of Aquatic Product Safety， School of Life Sciences， Sun Yat-sen University， Guangzhou 510275， China)

Abstract: Abstract: The study of aflatoxin biosynthesis regulatory mechanism has become a model system in investigating eukaryotic secondary metabolism. Rapid development of fungal genomics and other omics empowers us for genome mining， and the acquisition of gene expression profiling that could provide basis for research of aflatoxin biosynthesis regulatory network and other secondary metabolisms in fungi. The expression of fungal secondary metabolism genes is regulated by different types of transcription factors， including specific pathway transcription factors， global transcription factors， and various transcription factors in response to different environment impact. Researches on these transcription factors could help us to gain more comprehensive insights into aflatoxin biosynthesis regulatory network.