《生命科学》 2016, 28(1): 77-84

微管解聚蛋白Stathmin的研究进展

韩改净，赵晓航，许　杨*

(中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室，北京 100021)

摘　要：摘　要：微管解聚蛋白Stathmin 属于微管不稳定调节蛋白家族成员之一，具有促进微管解聚活性。Stathmin通过与细胞内多种蛋白质相互作用，参与细胞生命过程，包括调控细胞周期、细胞运动、细胞内信号转导、胞内物质运输等。Stathmin 由蛋白激酶，如MAPK、CDK 等磷酸化调控，在微管解聚中发挥重要作用。研究证实Stathmin 的高表达与食管癌的发生发展，对作用于微管的化疗药物的疗效相关。现就Stathmin 的结构特点、生物学功能、与其他分子的相互作用，及其与食管癌相关等方面的研究进展做一综述。

Advance in microtubule depolymerization protein Stathmin

HAN Gai-Jing， ZHAO Xiao-Hang， XU Yang*

(State Key Laboratory of Molecular Oncology， Cancer Institute，Chinese Academy of Medical Sciences， Beijing 100021， China)

Abstract: Abstract: Stathmin， a microtubule depolymerization protein， belongs to the microtubule-destabilizing protein family. It can interact with a variety of intracellular proteins to participate in the regulation of cell cycle， cell migration， signal transduction and transporter. Stathmin can be phosphorylated by a variety of intracellular kinases such as MAPK， CDK， which regulates depolymerization of microtubule. It has been confirmed that overexpression of Stathmin is associated with tumorigenesis and development of cancer， therapeutic response of anti-microtubule drugs. In this review， the biological characteristics of Stathmin， its interaction with other molecules， and relationship with esophageal cancer were described.