《生命科学》 2015, 27(11): 1418-1426

生物时钟与脂肪组织代谢整合机制研究进展

唐春奇，刘　畅*

(南京师范大学生命科学学院，江苏省分子医学生物技术重点实验室，南京 210023)

摘　要：摘　要：生物时钟广泛存在于各种生物体中，并调控机体的生理稳态。近年来的研究已部分阐明，中枢和外周时钟内在的反馈机制在能量代谢稳态中起重要作用。随着一天中能量需求的波动，哺乳动物脂肪组织的生理机能也表现出相应的昼夜变化。现对与脂肪组织生物时钟偶联的重要元件及其关联调控机制，尤其是基于小鼠模型得到的启发性研究成果进行综述。这些研究成果不仅阐明了生物时钟和脂肪组织能量代谢之间的内在联系，也从时间生物学的视角为治疗肥胖等代谢性疾病提供了潜在的药物靶点。

Advances on the relationship between the circadian clock and metabolism in adipose tissue

TANG Chun-Qi， LIU Chang*

(Jiangsu Key Laboratory for Molecular and Medical Biotechnology， College of Life Sciences， Nanjing Normal University， Nanjing 210023， China)

Abstract: The circadian clock exists broadly in the organisms， and regulates the body’s physiological steady state. Recent studies have partially elucidated the intrinsic feedback mechanisms through which central and peripheral clocks regulate metabolic homeostasis. Adipose physiology shows prominent variation during a day， responding to the changes of energy demands. This review will summarize the important components and mechanisms of adipose clock entrainment， particularly highlighting instructive studies carried out in mice. These studies not only illustrate intricate connections between the clock and metabolism in adipose tissue， but also provide potential drug targets to treat metabolic diseases including obesity from the view of chronobiology.