《生命科学》 2015, 27(11): 1409-1407

代谢生物钟研究进展

陈思禹，钱近春，刘　畅*

(南京师范大学生命科学学院，江苏省分子医学生物技术重点实验室，南京 210023)

摘　要：摘　要：生物时钟大致以24 h 为一个周期，参与调节一系列代谢和生理功能。流行病学和遗传学的相关证据显示，生物时钟的紊乱直接导致许多病理状况，包括睡眠失调、抑郁、代谢综合征和癌症。在分子水平上，生物时钟系统的组成元件与细胞代谢的调控因子之间存在功能性的相互作用：一方面，生物时钟可以调控多种代谢途径；另一方面，代谢物的供给和进食行为也可以反过来作用于生物时钟。进一步理解生物时钟节律和细胞代谢的相互调节作用，将为代谢性疾病的干预治疗提供新的理论基础。

The molecular mechanism for the integration of circadian clock and energy metabolism

CHEN Si-Yu， QIAN Jin-Chun， LIU Chang*

(Jiangsu Key Laboratory for Molecular and Medical Biotechnology， College of Life Sciences， Nanjing Normal University， Nanjing 210023， China)

Abstract: Abstract: Circadian rhythms occur with a periodicity of approximately 24 h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions， including sleep disorders， depression， metabolic syndrome and cancer. Intriguingly， several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways， metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic interventions against specific metabolic disorders.