《生命科学》 2015, 27(10): 1280-1284

铁过载与骨质疏松的关系

许　梓1，2，李金桥2，孙维佳1，2，凌树宽2，靳小艳2，常彦忠1*，李英贤2*

(1 河北师范大学生命科学学院，石家庄 050024；2 中国航天员科研训练中心航天医学基础与应用国家重点实验室，北京 100094)

摘　要：摘　要：近来研究表明，铁过载与骨质疏松有密切的关系。遗传性血色素沉着症和地中海贫血症等铁代谢紊乱的疾病患者中都伴随有不同程度的骨质疏松现象。另外，长期在轨飞行环境下，航天员出现机体铁沉积现象，同时，骨丢失情况十分严重，每月的骨丢失量约与地面上绝经后妇女每年的骨丢失量相当。铁水平升高能够抑制成骨细胞的分化，降低成骨细胞功能，成骨能力下降，骨形成受到抑制。铁沉积的同时，能够促进破骨细胞活性，增强骨吸收的能力，造成机体骨量减少，导致骨质疏松。铁调素能够作用于成骨细胞，随着铁调素剂量的增加，成骨细胞中与骨形成相关的基因表达量明显升高。铁调素还能作用于破骨细胞，促进破骨细胞的分化。在预防和治疗骨质疏松方面，有实验证明，铁螯合剂和铁调素都有治疗骨质疏松的作用。利用铁调素调节机体铁代谢平衡，降低铁过载程度，为日后临床治疗骨质疏松提供了理论支持。

Iron overload and osteoporosis

XU Zi1，2， LI Jin-Qiao2， SUN Wei-Jia1，2， LING Shu-Kuan2， JIN Xiao-Yan2， CHANG Yan-Zhong1*， LI Ying-Xian2*

(1 Laboratory of Molecular Iron Metabolism， College of Life Science， Hebei Normal University， Shijiazhuang 050024， China; 2 State Key Laboratory of Space Medicine Fundamentals and Application， China Astronaut Research and Training Center， Beijing 100094， China)

Abstract: Abstract: Recent researches indicate that iron overload is closely related with osteoporosis. Osteoporosis is a frequent problem in disorders characterized by iron overload， such as the thalassemias and hereditary hemochromatosis. Furthermore， long-duration space flight can increase body iron stores and induce bone loss in astronauts. Iron overload can inhibit osteoblast differentiation and function， which leads to reduced bone formation. Meantime， iron overload can enhance osteoclast function and increase bone absorption. Thus， iron overload can induce osteoporosis. Hepcidin has been found to be a main regulator of iron homeostasis， recent studies demonstrate that liver hepcidin level is associated with osteoporosis. Hepcidin can regulate osteoblast function， and enhance the
    bone formation gene expression in a dose dependent manner. Moreover， hepcidin can significantly facilitate osteoclast differentiation in vitro. As iron overload and osteoporosis are closely associated， the approaches for decreasing iron overload may have clinical potential for treatment and prevention of osteoporosis.