《生命科学》 2015, 27(10): 1246-1254

miR-302/367家族研究进展

马　腾1，李　敬2，李　炯1，周西坤1*

(1 四川大学华西医院生物治疗国家重点实验室/生物治疗协同创新中心，成都 610041；2 四川大学华西口腔医学院口腔疾病研究国家重点实验室，成都 610041)

摘　要：摘 要：MicroRNAs (miRNAs) 是一类长度约为22 nt 的内源性小分子非编码RNA，几乎参与了机体生命活动的所有过程。MicroRNA-302/367 (miR-302/367) 家族，包括miR-302a/b/c/d 和miR-367 等成员。近些年，人们对miR-302/367 家族在胚胎干细胞的自我更新与多能干细胞的诱导机制进行较为深入的研究。此外，该家族在肿瘤和炎症反应等方面调控作用也日益受到关注。现就miR-302/367 的功能研究进展作一综述。

Current progress in understanding the function of miR-302/367 cluster

MA Teng1， LI Jing2， LI Jiong1， ZHOU Xi-Kun1*

(1 State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy， West China Hospital， Sichuan University， Chengdu 610041， China; 2 State Key Laboratory of Oral Diseases， West China College of Stomatology， Sichuan University， Chengdu 610041， China)

Abstract: Abstract: MicroRNAs (miRNAs) are a class of ~22 nt endogenous small regulatory non-coding RNAs， which have been implicated in almost all the life processes. The microRNA-302/367 (miR-302/367) cluster contains several members such as miR-302a/b/c/d and miR-367. The molecular mechanism of miR-302/367 involved in embryonic stem cell self-renewal and induced pluripotent stem cells has been well investigated in the past few years. Moreover， its regulating role in tumor and inflammation is also getting more attention. This paper reviews the progress in understanding the function of miR-302/367.