《生命科学》 2015, 27(10): 1237-1245

生物时钟调控DNA损伤反应的研究进展

唐小利，郭志刚，刘　畅*

(南京师范大学生命科学学院江苏省分子医学生物技术重点实验室，南京 210023)

摘　要：摘 要：随着地球的自转，哺乳动物的许多生理和行为都表现出以24 h 为周期的节律性振荡。生物时钟是昼夜节律产生的物质基础。在分子水平上，生物时钟由一组高度保守的时钟基因及其编码的蛋白质形成的转录- 翻译反馈环路组成。它控制着许多生化反应的进行，包括细胞对基因毒性刺激等环境因素的反应。最近的研究发现，生物时钟在细胞的DNA 损伤反应过程( 包括DNA 修复、DNA 损伤检验点以及细胞凋亡)中发挥着重要的调控作用。深入了解其中的机制将为治疗相关疾病提供潜在的药物靶点，也可指导开发新的治疗方案，如时辰疗法。

Advances in the regulation of DNA damage response by the circadian clock

TANG Xiao-Li， GUO Zhi-Gang， LIU Chang*

(Jiangsu Key Laboratory for Molecular and Medical Biotechnology， College of Life Sciences， Nanjing Normal University， Nanjing 210023， China)

Abstract: Abstract: With the rotation of the earth， many physiologies and behaviors of mammals exhibit oscillations with a period of 24 h. The circadian clock is the basis of these circadian rhythms. At the molecular level， the circadian clock consists of transcription-translation feedback loops formed by a set of highly conserved circadian genes and their proteins. It controls many biochemical reactions， including cellular responses to environmental factors such as genotoxic stimuli. It is recently reported that the circadian clock plays an important role in regulating the cellular responses to DNA damage including DNA repair， DNA damage checkpoints and apoptosis. A better understanding of the mechanisms will provide potential drug targets for the related diseases， and also guide development of new therapeutic regimens such as chronotherapy.