《生命科学》 2006, 18(3):

CD8⁺ T细胞在多发性硬化中的致病性作用

梅云华， 徐凌云^*

上海交通大学医学院 上海市免疫学研究所，中国科学院上海生命科学研究院/上海交通大学医学院 健康科学中心，上海 200025

摘　要：摘　要：多发性硬化是T细胞介导的自身免疫性疾病。先前对它的研究大多集中在CD4⁺ T细胞的致病和调节性作用上，但是，近几年来越来越多的证据表明CD8⁺ T细胞也参与多发性硬化的病理损伤过程。CD8⁺ T细胞存在于MS病灶部位，髓鞘抗原特异性CD8⁺ T细胞也从MS患者的血液和脑脊液中分离得到，CD8⁺ T细胞通过直接杀伤或释放细胞因子和趋化因子等间接参与MS的病理过程。本文就近几年关于CD8⁺ T细胞在多发性硬化中的致病性作用的研究进展予以介绍。
关键词：CD8⁺ T细胞；CD4⁺ T细胞；多发性硬化；实验性自身反应性脑脊髓炎

The pathogenic roles of CD8+ T cells in multiple sclerosis

MEI Yun-Hua, XU Ling-Yun^*

Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine

Abstract: Abstract:  Multiple sclerosis (MS) is a T cell mediated autoimmune disease. Previous researches focus on the roles of CD4⁺ T cells, including the pathogenic and immune-regulatory roles. However, more and more evidences show that CD8⁺ T cells act as an important factor in the development of MS. CD8⁺ T cells were founded in the lesions of MS, and myelin antigen specific CD8⁺ T clones were isolated from MS patients. The autoreactive CD8⁺ T cells can damage target cells directly or amplify local inflammation through secreting cytokines and chemokines. Illustrating the roles of CD8⁺ T cells in MS will help us better understand the mechanisms of MS and find new prevention and therapeutic methods. 
Key wards:  CD8⁺ T cells; CD4⁺ T cells; multiple sclerosis; experimental autoimmune encephalomyelitis