《生命科学》 2006, 18(3):

端粒结合蛋白TRF2的研究进展

张永炜^1,2，缪泽鸿¹，丁　健^1*

1中国科学院上海生命科学研究院药物研究所新药研究国家重点实验室，上海 201203；2中国科学院研究生院，北京 100049

摘　要：摘　要：端粒DNA结合蛋白 TRF2 (TTAGGG repeat binding factor-2)以二聚体形式通过Myb结构域与端粒重复序列TTAGGG结合，并与TRF1、TIN2、Rap1、TINT1及POT1蛋白组成Shelterin蛋白复合物，协同在端粒动态平衡维持过程中起关键作用，进而影响整个基因组的稳定性。此外，TRF2在细胞DNA损伤应答过程中可能发挥重要作用。本文将对TRF2结构和功能研究的最新进展进行综述。
关键词：端粒结合蛋白TRF2；端粒；DNA损伤响应系统

Telomere binding protein TRF2

ZHANG Yong-Wei^1,2, MIAO Ze-Hong¹, DING Jian^1*

1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China; 2 Graduate School of CAS, Beijing 100049, China

Abstract: Abstract: TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TIN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3{$39} G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.
Key words: TRF2; telomere; DNA damage response system