《生命科学》 2015, 27(9): 1174-1180

多种免疫相关的细胞因子基因多态性与肝细胞癌的关联性的研究进展

张亚龙1，高建梅2，严新民2*

(1 昆明理工大学医学院，昆明 650504；2 云南省第一人民医院基础医学研究所云南省临床分子生物学中心，云南省出生缺陷与遗传病重点实验室，昆明 650032)

摘　要：摘　要：作为体内免疫系统的重要组成成分，免疫相关的细胞因子在抗病毒、细胞生长以及受伤组织修复方面具有重要功能。其基因的单核苷酸多态性会影响机体细胞因子的表达水平，造成宿主血清含量的差异，进而影响肝炎病毒的感染进程与临床转归，和机体发展成肝细胞癌具有密切关系。现就以下几种重要的细胞因子的基因多态性与肝细胞癌的最新发现进行综述。

Research progress of the relationship between multiple immune-related cytokines gene polymorphisms and hepatocellular carcinoma

ZHANG Ya-Long1， GAO Jian-Mei2， YAN Xin-Min2*

(1 Medical Faculty of Kunming University of Science and Technology， Kunming 650504， China; 2 Provincial Key Laboratory for Birth Defects and Genetic Diseases， Center of Clinical Molecular Biology， Institute of Basic Medical Sciences， The First People’s Hospital of Yunnan Province， Kunming 650032， China)

Abstract: Abstract: Immune-related cytokines， acting as the important component of the body’s immune system， play significant roles in anti-virus， cells growth and rehabilitation of wounded tissue. Single nucleotide polymorphisms (SNPs) in cytokine genes could influence their expression level， and result in discrepancy of host serum content， the course of hepatitis virus infection and clinical prognosis. Therefore， these SNPs have a close relationship with hepatocellular carcinoma development and progression. This review summarizes recent findings on the relationship between gene polymorphisms of the several key cytokines and hepatocellular carcinoma.