《生命科学》 2015, 27(9): 1168-1173

CUEDC2介导肿瘤发生相关机制的研究进展

于灏婷1，李彦姝2*

(1 中国医科大学七年制临床医学系，沈阳 110001；2 中国医科大学基础医学院细胞生物学
    教研室，卫生部细胞生物学重点实验室暨教育部医学细胞生物学重点实验室，沈阳 110001)

摘　要：摘　要：CUEDC2 是一种普遍存在于许多肿瘤中的蛋白质，与肿瘤的发生以及预后治疗存在着紧密关系，近年来越来越受到广泛的关注和重视。现从CUEDC2 在乳腺癌中的作用，对有丝分裂细胞周期、炎症反应的信号通路和巨噬细胞的调节，以及CUEDC2 与一些新兴领域如褪黑素以及热休克蛋白的关系入手，对CUEDC2 介导肿瘤发生相关机制的研究进展进行综述。

Advance of study on the related mechanism of the tumor mediated by CUEDC2

YU Hao-Ting1， LI Yan-Shu2*

(1 Major of Clinical Medicine， China Medical University， Shenyang 110001， China; 2 Key Laboratory of Cell Biology of Ministry of Public Health and Key Laboratory of Medical Cell Biology of Ministry of Education， Department of Cell Biology， College of Basic Medical Science， China Medical University， Shenyang 110001， China)

Abstract: Abstract: CUEDC2 is a kind of protein that has been found in many tumors. It has been shown that there’s a close relationship between CUEDC2 and the formation of tumors， also the subsequent treatment， which has been paid more attention in recent years. Therefore， this article summarizes the advance of study on the related mechanism of the tumorigenesis mediated by CUEDC2 from the effect of CUEDC2 in breast cancer， the signal pathway and macrophage in inflammation， melatonin， heat shock protein and many other aspects.