《生命科学》 2015, 27(9): 1140-1145

miRNA在类风湿性关节炎中的研究进展

赵　瑜1，2，王　林1，2，潘继红1，2，3*

(1 济南大学-山东省医学科学院医学与生命科学学院，济南 250062；2 山东省医药生物技术研究中心，济南 250062；3 山东省罕少见病重点实验室，济南 250062)

摘　要：摘　要：miRNA 是真核生物内源性基因编码的、长度约为22 nt 的单链RNA，它主要通过与目标mRNA的3′ 端相结合，在翻译水平调控基因的表达。近年来发现，miRNA 在类风湿性关节炎中与细胞的异常增殖、侵袭、凋亡等相关，并可参与局部病灶的免疫反应。现将对miRNA 在类风湿性关节炎中表达、功能和如何参与调控免疫反应作一综述。

The potential role of miRNA in rheumatoid arthritis

ZHAO Yu1，2， WANG Lin1，2， PAN Ji-Hong1，2，3*

(1 School of Medicine and Life Science， University of Jinan-Shandong Academy of Medical Science， Jinan 250062， China; 2 Shandong Medicinal Biotechnology Centre， Jinan 250062， China; 3 Key Laboratory for Rare Disease of Shandong Province， Jinan 250062， China)

Abstract: Abstract: MiRNAs are endogenous， non-coding， single-stranded RNAs with about 21 nucleotides in length. They are known as post-transcriptional regulators by binding to 3′-untranslated region of their target genes. Recently， it has been shown that miRNA was associated with the pathogenesis of rheumatoid arthritis (RA) in various aspects， such as chronic inflammation and hyperplasia in the synovial lining cells. The purposes of this review are to provide an overview on our current understanding of miRNA expression and function in RA and to underscore the potential for clinical application of miRNAs in RA.