《生命科学》 2015, 27(7): 928-935

RNA编辑在肿瘤中的研究进展

何安邦1，汪　翔1，张　蒙1*，梅红兵1，2*

(1 安徽医科大学深圳市第二人民医院临床医学院泌尿外科，深圳 518000；2 深圳市第二人民医院泌尿外科，深圳市泌尿生殖系统肿瘤研究重点实验室，深圳 518035)

摘　要：摘　要：RNA 编辑参与转录后RNA 的调控，已证明与多种肿瘤发生发展相关，现逐渐成为肿瘤领域研究的热点。总结发现RNA 编辑主要通过作用于致瘤相关基因( 如抑癌基因、致癌基因) 转录后RNA 来发挥其相应作用。随着RNA 编辑在肿瘤中的研究深入，可进一步从转录后水平阐明肿瘤发生发展的潜在机制，为肿瘤诊治提供新的思路。

Progression of RNA editing in tumor research

HE An-Bang1， WANG Xiang1， ZHANG Meng1*， MEI Hong-Bing1，2*

(1 Urology Department， Shenzhen Second People’s Hospital， Clinical Medicine College， Anhui Medical University，Shenzhen 518000， China; 2 Shenzhen Key Laboratory of Genitourinary Tumor， Department of Urology，Shenzhen Second People’s Hospital， Shenzhen 518035， China)

Abstract: Abstract: RNA editing is involved in the regulation of post-transcriptional RNA， which is uncovered to be associated with the growth and progression of many cancers， becoming a hot spot of tumor research. It is concluded that RNA editing contributed to the tumorigenesis process mainly by working on the tumor-related genes， such as cancer suppressor genes and oncogenes. As the research of RNA editing in tumor continues， the underlying mechanisms may be further elucidated at the post-transcriptional RNA level， providing a new theoretical basis for tumor diagnosis and therapy.