《生命科学》 2015, 27(7): 908-913

肝细胞衰老及其在肝脏疾病和肝细胞移植中作用的研究进展

谭　超1*，刘朝奇2，沈雪莲3，覃玉娥3

(1 三峡大学第一临床医学院/宜昌市中心人民医院，宜昌 443003；2 三峡大学分子生物学研究所，宜昌 443002；3 三峡大学医学院，宜昌 443002)

摘　要：摘　要：细胞衰老(cellular senescence) 是指细胞生理功能的衰减，包括增殖能力下降、细胞周期停滞、对促凋亡应激不敏感、衰老相关基因和蛋白质表达增加，伴有形态学衰老改变。衰老肝细胞在形态和功能上已经发生了很多根本性的改变。越来越多的证据表明，肝细胞衰老和衰老信号通路(p53-p21-pRb 和p16-pRb) 在多种肝脏疾病进展和肝细胞移植效果中发挥了重要作用。就近年来肝细胞衰老的分子机制及其与肝脏疾病和肝细胞移植关系的最新研究进展进行综述，以期为衰老相关肝脏疾病治疗和肝细胞移植提供新思路。

Research progress of hepatocyte senescence and its function in liver diseases    and hepatocyte transplantation

TAN Chao1*， LIU Chao-Qi2， SHEN Xue-Lian3， QIN Yu-E3

(1 First College of Clinical Medical Science， China Three Gorges University/Yichang Central People’s Hospital， Yichang 443003， China; 2 Institute of Molecular Biology， China Three Gorges University， Yichang 443002， China; 3 Medical Science College of China Three Gorges University， Yichang 443002， China)

Abstract: Abstract: Cell senescence refers to the attenuation of physiological function of cells including decreased proliferation ability， cell cycle arrest， apoptosis resistance and altered gene expression， accompanied by morphological changes of senescence. Senescent hepatocytes have many fundamental changes in morphology and function. There is increasing evidence that hepatocyte senescence and senescence pathways (p53-p21-pRb and p16-pRb) play a central role in age-dependent disease of the liver and hepatocyte transplantation. In this review， we summarize the current concepts in the molecular mechanisms of hepatocyte senescence and correlate these theories with the available literature on liver diseases and hepatocyte transplantation in order to provide new ideas for the treatment of liver diseases and hepatocyte transplantation.