《生命科学》 2015, 27(7): 903-907

microRNA对衰老相关分子SIRT1调控作用的研究进展

杨　婕，刘朝奇*

(三峡大学分子生物学研究所，宜昌 443002)

摘　要：摘　要：沉默信息调节因子1 (silent information regulator 1， SIRT1) 是NAD+ 依赖的III 类组蛋白去乙酰化酶，是衰老相关信号通路中的重要分子，参与细胞衰老过程。微小RNA (microRNA， miRNA) 是一类长度约为22 nt 的内源性非编码小分子RNA，通过影响靶mRNA 的稳定性或抑制其翻译从而对基因进行转录后表达的调控。研究表明，miRNAs 可以通过调控SIRT1 的表达，促进细胞衰老。现就miRNA 对衰老相关分子SIRT1 的调控作用进行概述。

Research progress on the role of miRNAs in the regulation of SIRT1

YANG Jie， LIU Chao-Qi*

(Institute of Molecular Biology， China Three Gorges University， Yi Chang 443002， China)

Abstract: Abstract: SIRT1 is a class III histone NAD+ dependent deacetylase， which is an important molecule in agingrelated signaling pathway， and plays a pivotal role in the cell aging process. MicroRNAs (miRNAs) are endogenous， ~22 nucleotides， small non-coding RNAs which typically regulate gene expression after transcription by affecting the stability or translation of targeted mRNA. Studies have shown that miRNAs can promote cellular senescence by regulating the expression of SIRT1. This review describes the potential functions of miRNAs in the regulation of SIRT1.