《生命科学》 2015, 27(7): 892-897

Sin3A蛋白调节细胞功能综述

张梓卉，王振东，白光宇，张 娜，李　彤，雷　蕾*

(哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081)

摘　要：摘　要：SIN3 转录调控蛋白家族成员A (SIN3 transcription regulator family member A， Sin3A) 包含许多蛋白质相互作用结构域，是一个多蛋白的转录共阻遏复合物的核心组分，通过结合该转录阻遏复合物中的组蛋白去乙酰化酶(histone deacetylase， HDAC) 起到转录抑制的作用。Sin3A 通过与不同的功能蛋白，如Mad (Max dimerization protein)-Max (MYC associated factor X)、Myc (Myelocytomatosis oncogene)、甲基CpG 结合蛋白2(Methyl CpG binding protein 2， Mecp2) 等相互作用，在细胞增殖、分化、凋亡，肿瘤的形成、细胞周期调控、
    植入前胚胎发育以及组织器官发育过程中扮演重要角色。近来有研究表明，Sin3A 在体细胞重编程过程中显著上调，因此，Sin3A 可能在体细胞重编程中也起到重要作用。

Sin3A regulates cell functions

ZHANG Zi-Hui， WANG Zhen-Dong， BAI Guang-Yu， ZHANG Na， LI Tong， LEI Lei*

(Department of Histology and Embryology， Harbin Medical University， Harbin 150081， China)

Abstract: Abstract: SIN3 transcription regulator family member A (Sin3A) contains a lot of protein interaction domains. It is a core component of transcription repression complex， in which it can repress transcription through combining histone deacetylase (HDAC). By interacting with other proteins， such as Mad-Max， Myc， Mecp2， Sin3A plays very important roles in cell proliferation， differentiation， apoptosis， formation of tumor， cell cycle regulation， preimplantation embryonic development， tissues and organs development. Recent research reported that Sin3A was upregulated significantly in somatic cell reprogramming， indicating a potential function of Sin3A in this process.