《生命科学》 2015, 27(7): 827-836

斑马鱼hypocretin/orexin能神经系统的研究进展

杜旭飞*，杜久林*

(中国科学院上海生命科学研究院神经科学研究所，中国科学院脑科学卓越创新中心，神经科学国家重点实验室，上海 200031)

摘　要：摘　要：外侧下丘脑分泌的神经肽——下丘脑泌素/ 食欲素(hypocretin/orexin) 是哺乳动物中一种重要的调节睡眠和清醒的多肽类神经调质，hypocretin/orexin 能神经系统功能缺陷可造成发作性嗜睡病。由于哺乳动物神经系统的复杂性，hypocretin/orexin 能神经系统调节睡眠和清醒状态的机制至今仍不清楚。综述了近十年来斑马鱼hypocretin/orexin 能神经系统的研究进展。基于其大脑结构简单的特点，斑马鱼是揭示hypocretin/orexin 能神经系统结构和功能的重要模型。

Structure and function of the hypocretinergic/orexinergic system in zebrafish

DU Xu-Fei*， DU Jiu-Lin*

(State Key Laboratory of Neuroscience， CAS Center for Excellence in Brain Science， Institute of Neuroscience， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China )

Abstract: Abstract: Hypocretin/orexin (hcrt)， a neuropeptide secreted by certain lateral hypothalamic neurons， is an important neuromodulator in regulating sleep and wakefulness in mammals. Defects in the hypocretinergic/orexinergic system lead to the sleep disorder narcolepsy. However， it remains largely unknown how the system regulates sleep and wakefulness. Here， we summarize the progress over the past decade in the structure and function of the hypocretinergic/orexinergic system in zebrafish. Due to its simplicity， zebrafish hypocretinergic/orexinergic system can serve as an ideal model for studying the mechanism of sleep/wakefulness regulation.