《生命科学》 2015, 27(7): 807-812

Wnt信号膜质转导的机制

贾莹莹，李　林*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，分子生物学国家重点实验室，上海 200031)

摘　要：摘　要：Wnt 信号通路是一条高度保守的信号转导通路，在生物体多个发育过程以及一系列疾病发生中发挥重要作用。Wnt 信号通路重要的生物学功能和复杂的信号转导调控网络引起了人们广泛和持续的研究兴趣。介绍了经典Wnt 信号通路信号转导的分子框架，结合自身实验室新的研究发现，重点阐述Wnt 信号由细胞膜上向细胞质内转导的机制。

The mechanism of Wnt signal transferring from membrane to cytoplasm

JIA Ying-Ying， LI Lin*

(State Key Laboratory of Molecular Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Wnt signaling pathway is a highly conserved signal transduction pathway， and plays important roles in multiple biological developmental processes and diseases. The biological function and complicated signal transduction network have aroused the widespread study interest. This review introduces the molecular framework of classical Wnt signaling pathway， combined with the findings from our own laboratory， focuses on the mechanism of Wnt signaling transferring from cell membrane to cytoplasm.