《生命科学》 2015, 27(5): 640-646

免疫脂质体的研究进展

王贺丽1，韩文琦2，朱　杰3，甄宇红2*，张树彪4*

(1 大连医科大学第一临床学院 (本硕连读)，大连 116044；2 大连医科大学药学院，大连 116044；3 大连医科大学附属第二医院，大连 116027；4 大连民族学院生物技术与资源利用国家民委-教育部重点实验室，大连 116600)

摘　要：摘　要：免疫脂质体作为靶向药物传递体系，具有靶向性、缓释性以及细胞亲和性等独特的优势，成为近年来备受关注的药物载体。免疫脂质体可作为肿瘤化疗药物、放疗药物、基因治疗药物及肿瘤影像诊断剂的载体，用于肿瘤的靶向治疗和检测，在肿瘤临床治疗和诊断中有着广阔的应用前景。综述了免疫脂质体的制备及在肿瘤治疗中的应用进展，以期为免疫脂质体的研究和应用提供参考。

Advances in studies of immunoliposomes

WANG He-Li1， HAN Wen-Qi2， ZHU Jie3， ZHEN Yu-Hong2*， ZHANG Shu-Biao4*

(1 The First Clinical College (Accelerated Degree)， Dalian Medical University， Dalian 116044， China; 2 College of Pharmacy， Dalian Medical University， Dalian 116044， China; 3 The Second Affiliated Hospital of Dalian Medical University， Dalian 116027， China; 4 SEAC-ME Key Laboratory of Biotechnology and Bio-resource Utilization， Dalian Nationalities University， Dalian 116600， China)

Abstract: Abstract: Immunoliposomes have attracted much attention as targeting drug carriers in recent years， because of their molecular targeting， slow-releasing， cell affinity and other unique advantages. Immunoliposomes can be used in tumor therapy as carriers for chemotherapeutics， radiotherapeutic drugs， gene therapeutic drugs and tumor imaging diagnostic agents， and show a broad prospect of application in clinical treatment and diagnosis. This paper
    reviews the progress in preparation of immunoliposomes and its application in tumor therapy， to provide a reference for the research and application of immunoliposomes.