《生命科学》 2015, 27(5): 595-600

WDR蛋白在肿瘤发生发展中的作用机制

热孜宛古丽·阿卜力米提，宋　丹，马正海*

(新疆大学生命科学与技术学院，乌鲁木齐 830046)

摘　要：摘　要：WDR 蛋白家族(Trp-asp repeat protein family) 是含有多个保守WD 基序(WD motif) 的蛋白质类，广泛存在于真核生物中。近年，WDR 蛋白的研究已成为细胞生物学和病理学研究的新热点。目前已知多种WDR 蛋白在肿瘤细胞中异常表达，并通过调节信号转导、细胞周期、泛素化、转录和RNA 加工等生物过程促使肿瘤发生。现对WDR 蛋白在肿瘤发生发展中的作用机制作一综述。

The mechanisms of WDR protein in tumor genesis and progression

ABULIMITI Reziwanguli， SONG Dan， MA Zheng-Hai*

(College of Life Science and Technology， Xinjiang University， Urumqi 830046， China)

Abstract: Abstract: WDR protein family (Trp-Asp repeat protein family) contains multiple conserved WD motifs and is broadly distributed in almost all of eukaryotes. In recent years， the research of WDR proteins has become the hotspots in cell biology and pathology. At present， it has been proven that a number of WDR proteins are irregularly expressed in tumor cells and play important roles in regulating signal transduction， cell cycle， ubiquitination， transcription， RNA processing and other biological processes to promote tumor genesis. In this review， we will summarize the mechanisms of WDR protein in tumor genesis and progression.