《生命科学》 2015, 27(5): 590-594

DNA甲基化修饰与原发性高血压发病关联的研究

范　瑞，钟琦珑，毛书奇，朱　雯，张莉娜*

(宁波大学医学院预防医学系浙江省病理生理学技术研究重点实验室，宁波 315211)

摘　要：摘　要：DNA 甲基化作为最早发现的一种表观遗传修饰方式，是目前研究的热点之一。甲基化修饰虽不改变DNA 序列，但对基因的表达起重要的调节作用。原发性高血压作为全球主要的公共健康问题，其发生是遗传与环境等多因素共同作用的结果，被认为是受DNA 甲基化等表观遗传学规律调控的人类重要疾病。现就近年来有关DNA 甲基化与原发性高血压发病关联的研究进展作一综述。

The research of DNA methylation and its causation in the pathogenesis of essential hypertension

FAN Rui， ZHONG Qi-Long， MAO Shu-Qi， ZHU Wen， ZHANG Li-Na*

(Department of Preventive Medicine， Zhejiang Provincial Key Laboratory of Pathophysiology， School of Medicine， Ningbo University， Ningbo 315211， China)

Abstract: Abstract: DNA methylation， one of the earliest discovered epigenetic manners， is currently a hot topic in life sciences. Although methylation does not change DNA sequence， it plays an important regulatory role in the process of gene expression. Besides， as one of the major public health problems， essential hypertension (EH) is an important human disease， caused by a combination of genetic and environmental factors， which is considered to be regulated by epigenetic， such as DNA methylation. This paper summarizes recent progress regarding the association between DNA methylation and the pathogenesis of essential hypertension.