《生命科学》 2015, 27(5): 574-581

TNF-α在抑郁症中的作用和机制研究

马　柯1，张洪秀2，王广燕1，王　伟1 ，刘宗涛3*

(1 青岛大学医学院，青岛 266073；2 云南省第一人民医院，昆明 650032；3 青岛市第三人民医院，青岛 266003)

摘　要：摘　要：抑郁症是一种情感精神疾病，临床上以显著而持久的心境低落为主要特征。抑郁症严重危害人们身心健康，降低生活质量，增加社会负担。抑郁的产生原因比较复杂，发病机制存在多种假说。在过去的几十年，虽然对于抑郁症的研究取得了一定的进展，但其确切的病因及病理生理机制目前仍不明确。近期，研究显示，促炎性细胞因子，尤其是肿瘤坏死因子-α (tumor necrosis factor-α， TNF-α) 在抑郁症的发生、发展及临床药理机制中扮演着重要角色。现通过对TNF-α 的生物学特征、在抑郁症发病和抗抑郁治疗中的作用、基因多态性与抑郁症关联性以及未来的应用与展望等进行综述，以期从多方面阐明TNF-α 在抑郁症中的作用。

Tumor necrosis factor-α and its role in depression

MA Ke1， ZHANG Hong-Xiu2， WANG Guang-Yan1， WANG Wei1， LIU Zong-Tao3*

(1 Medical College， Qingdao University， Qingdao 266073， China; 2 First People's Hospital of Yunnan Province， Kunming 650031， China; 3 The Third People's Hospital of Qingdao， Qingdao 266003， China)

Abstract: Abstract: Depression is a mental disorder characterized by a pervasive and persistent low mood in clinic， which is associated with disability and reduced quality of life， as well as a significant social burden. Due to the multifactorial etiology factors of depression， there is a variety of pathogenesis hypothesis. Up to now， however， the pathogensis of depression still remains poorly understood. Most recently， there is a great deal of evidence that the pro-inflammatory cytokines， specifically， tumor necrosis factor-α (TNF-α) play a critical role in the development of depressive disorders and the mechanism of antidepressant treatment. In this paper， we focus on recent progress of the relationship between TNF-α and depressive disorders， and illustrate its biological characteristics， role in the pathophysiology， genetic susceptibility and future applications.