《生命科学》 2015, 27(5): 558-563

建立在系统生物学基础上的精准医学

吴家睿1，2，3

(1 中国科学院上海生命科学研究院生物化学与细胞生物学研究所，上海 200031；2 中国科学院上海高等研究院，上海 201210；3 上海科技大学生命科学与技术学院，上海 201210)

摘　要：摘　要：面对生命复杂性的巨大挑战，研究者提出了整合基因组、蛋白质组和代谢组等多组学数据，以及整合从分子到生理病理表型数据的系统生物学研究策略，利用该策略建立以个体为中心的多层级人类疾病知识整合数据库，并在此基础上形成可用于疾病精确分类的生物医学知识网络，进而发展出未来能够为每个个体提供最好医疗护理的精准医学。

Precision medicine based on systems biology

WU Jia-Rui1，2，3

(1 Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China; 2 Shanghai Advanced Research Institute， Chinese Academy of Sciences， Shanghai 201210， China; 3 School of Life Sciences and Technology， ShanghaiTech University， Shanghai 201210， China)

Abstract: Abstract: Facing the grand challenges of biological complexity， researchers have developed the systems biology approaches for integrating data derived from genomics， proteomics and metabolomics and other omics， integrating data from molecular level to physiological and pathological levels. Based on the strategy and tools of systems biology， it is possible to build individual-centric biomedical database that consists of multilayered and highly interconnected biological parameters， and then construct a knowledge network of biomedical research， which could be used for new taxonomic classification of diseases. The biomedical knowledge-network and new taxonomy of diseases should support a so-called precision medicine that provides the best accessible medical-care for each individual.