《生命科学》 2006, 18(4):

低氧诱导因子-1α的翻译后化学修饰及其对活性的调控作用

康迅雷， 易 静^*

上海交通大学医学院细胞生物学教研室, 教育部细胞分化与凋亡重点实验室，上海200025

摘　要：摘　要：低氧诱导因子-1(hypoxia inducible factor-1, HIF-1)是参与调节机体氧平衡的重要转录因子。作为一种蛋白质，它的主要亚基HIF-1a受到多种翻译后的化学修饰，如泛素化、羟基化、乙酰化、类泛素化、磷酸化、巯基化等的影响，从而使其蛋白的稳定性、入核以及对下游基因的促转录活性受到调节。因此，研究HIF-1α的翻译后修饰，不仅有助于我们加深对HIF-1作为一个多种疾病的治疗靶标的认识，更能为我们理解类似转录因子自身的调控提供思路。
关键词：低氧诱导因子-1；化学修饰；翻译后修饰

The post-translational chemical modification and its regulating effects on the activity of hypoxia inducible factor-1α

KANG Xun-Lei, YI Jing^*

Department of Cell Biology, Key Laboratory of the Education Ministry for Cell Differentiation and Apoptosis, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China

Abstract:
Abstract: Hypoxia inducible factor-1( HIF-1 ) is an important transcription factor in oxygen homeostasis of the organism. As a protein, its major subunit HIF-1a is subjected to a variety of the post-translational chemical modification, such as ubiquitination, hydroxylation, acetylation, sumolyation, phosphorylation, sulfhydrylation, etc. By these modifications, the stability, cytoplasmic-nuclear trafficing and transcriptional activity of HIF-1a are regulated. Therefore studies in this aspect are helpful in understanding not only HIF-1α as a therapeutic target for the diseases but also the regulation of other similar transcriptional factors.
Key words: HIF-1; chemical modification; post-translational modification