《生命科学》 2015, 27(4): 471-476

miR-146a/b在动脉粥样硬化疾病中的研究进展

王文俏1#，刘　露1#，许　馨1，任威瑞1，尚　丹2，孙绍光1*

(1 河北医科大学基础医学院生物化学与分子生物学教研室，河北省医学生物技术重点实
    验室，石家庄 050017；2 北京铁路局石家庄卫生防疫站，石家庄 050000)

摘　要：摘　要：动脉粥样硬化是冠心病等心血管疾病的病理学基础。血管内皮细胞、血管平滑肌细胞和单核/ 巨噬细胞是参与动脉粥样硬化发生发展的重要因素。microRNA 是一类内源性、长约22 个核苷酸的非编码RNA，能够参与调控众多生物学过程，与许多疾病密切相关。miR-146a/b 广泛表达于血管内皮细胞、平滑肌细胞和单核/ 巨噬细胞中，并通过作用于不同靶基因发挥其多样化的生物学功能，参与调控动脉粥样硬化。现就miR-146a/b 与动脉粥样硬化发生发展的关系作一综述。

The roles of miR-146a/b in atherosclerosis

WANG Wen-Qiao1#， LIU Lu1#， XU Xin1， REN Wei-Rui1， SHANG Dan2， SUN Shao-Guang1*

(1 Department of Biochemistry and Molecular Biology， Basic Medical College， Hebei Medical University， Hebei Laboratory of Medical Biotechnology， Shijiazhuang 050017， China; 2 Shijiazhuang Health and Epidemic Prevention Station， Beijing Railway Bureau， Shijiazhuang 050000， China)

Abstract: Abstract: Atherosclerosis， the major cause of cardiovascular disease， is a chronic inflammatory disease. Endothelial cells， vascular smooth muscle cells， and monocytes/macrophages are involved in the initiation and development of
    atherosclerosis. MicroRNAs are a class of endogenous non-coding RNA， containing about 22 nucleotides， which contribute to many biological processes and diseases. MiR-146a/b are widely detected in endothelial cells， vascular smooth muscle cells， and monocytes/macrophages， which participate in diverse biological functions through targeting several different atherosclerosis genes. Here， this review will summarize the relationship between miR-146a/b and atherosclerosis