《生命科学》 2015, 27(3): 406-416

杆状病毒病毒粒子结构与口服感染和系统感染的关系

侯典海，王曼丽，邓　菲，王华林，胡志红*

(中国科学院武汉病毒研究所，武汉 430071)

摘　要：摘　要：杆状病毒在其生命周期中形成了两种不同的病毒类型：出芽型病毒粒子(budded virus， BV) 和包埋型病毒粒子(occlusion derived virus， ODV)，其中ODV 负责口服感染，而BV 负责系统感染。它们又分别应用于不同的生物技术领域，如BV 可用于杆状病毒表达载体，而富含ODV 的多角体主要用于生物防治。近年来蛋白质组学的研究进展对BV 和ODV 的产生机理有了新的认识，现主要总结这方面的研究结果。

The structure differences of BV and ODV reflect their function for systematic and oral infection

HOU Dian-Hai， WANG Man-Li， DENG Fei， WANG Hua-Lin， HU Zhi-Hong*

(Wuhan Institute of Virology， Chinese Academy of Sciences， Wuhan 430071， China)

Abstract: Abstract: Baculovirus produces two phenotypes of progeny virions during its life cycle: budded virus (BV) and occlusion derived virus (ODV). BV is responsible for systematic infection in the host and has been used widely as foreign gene expression vector， while ODV is responsible for initiating oral infection and has been used for biological control. Recently， the proteomics researches on BV and ODV have revealed the structural similarity and differences between the two phenotypes. In this review， we summarize the relationship between the structure of BV and ODV and their functions of oral and systematic infection， as well as the impacts on future research and development.