《生命科学》 2015, 27(3): 363-373

微管蛋白的翻译后修饰及功能研究

高囡囡，鲍　岚*

(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，细胞生物学国家重点实验室，上海 200031)

摘　要：摘　要：微管是由α/β 微管蛋白(α/β-tubulin) 聚合形成的管状细胞骨架，在许多生物学过程中起着重要的作用。微管的结构与性质受到多种因素的调控，其中微管蛋白的翻译后修饰是一类重要的调控方式。主要介绍目前已发现的微管蛋白翻译后修饰种类，并讨论这些修饰的生物学功能与作用机制。

Post-translational modification of tubulin: classification， function and mechanism

GAO Nan-Nan， BAO Lan*

(State Key Laboratory of Cell Biology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Microtubule is one of cytoskeletons which possesses a hollow cylindrical structure and polymerized from α/β-tubulin heterodimer. It plays an important role during a diversity of biological processes. The structure and property of microtubule are regulated by various regulators， and the post-translational modification of tubulin is the important one. We herein summarize the classification of tubulin post-translational modification and discuss its functions and underlying mechanisms.