《生命科学》 2006, 18(4):

线粒体在细胞凋亡中的介导作用

白世平^1,2，罗绪刚^1,2*，吕　林^1,2

1中国农业科学院畜牧研究所矿物元素营养研究室, 北京100094; 2动物营养学国家重点实验室，北京100094

摘　要：摘　要：线粒体是细胞内产生能量的重要细胞器，被认为是细胞生存与死亡的调节中心。Bcl-2家族蛋白、内质网和溶酶体能引起线粒体膜通透性的改变，造成线粒体功能损伤，诱导细胞凋亡。本文主要综述线粒体在Bcl-2家族蛋白、内质网和溶酶体诱导细胞凋亡中作用的研究进展。
关键词：线粒体；细胞凋亡；内质网；溶酶体

Mitochondrial intervention action in apoptosis

BAI Shi-Ping^1,2, LUO Xu-Gang^1,2*, LV Lin^1,2

1 Mineral Nutrition Research Division, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100094, China; 2 State Key Laboratory of Animal Nutrition, Beijing 100094, China

Abstract: Abstract: Mitochondria are important intracellular organelles to supply energy and are regarded as central regulator of the decision between cellular survival and demise. The increase of permeability of mitochondrial membranes induced by Bcl-2 family proteins, endoplasmic reticulum and lysosomes can damage the function of mitochondria and induce apoptosis. This review introduces the recent research advances of the effects of mitochondria in apoptosis induced by Bcl-2 family proteins, endoplasmic reticulum and lysosomes.
Key words: mitochondria; apoptosis; endoplasmic reticulum; lysosome