《生命科学》 2015, 27(3): 289-293

外侧缰核：抑郁症的异度空间

崔一卉，胡海岚*

(中国科学院上海生命科学研究院神经科学研究所，上海 200031)

摘　要：摘　要：抑郁症是一种非常常见且严重的精神疾病，探索抑郁症的核心分子机制，寻找更有效、更关键、更直接的抗抑郁症药物靶点，成为现今抑郁症研究的新热点。现综述归纳总结抑郁症神经环路中的关键核心脑区外侧僵核的神经环路及在情绪调控中的生理功能，重点阐述其在抑郁症中的角色。

Hunting the “black dog” of depression: the functional implication of lateral habenula

CUI Yi-Hui， HU Hai-Lan*

(Institute of Neuroscience， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Depression is among the most common and most burdensome mental disorders today and has been a major research topic in neurosciences. In recent years， habenula， a brain structure that has critical roles in regulating stress response， aversive emotions and reward behaviors， has emerged as a major player in depression pathogenesis. In this review， we will discuss systematically the role of lateral habenula in emotion regulation and depression pathogenesis at the circuitry and cellular levels.