《生命科学》 2015, 27(3): 249-261

β肾上腺素受体与心力衰竭

宋　颖，胡耀豪，肖瑞平*

(北京大学分子医学研究所，生命科学联合中心，代谢及心血管分子医学北京市重点实验室，北京 100871)

摘　要：摘 要：β 肾上腺素受体中的β1 和β2 亚型是调节心脏功能最重要的两种蛋白。在此将阐述β 肾上腺素受体亚型信号转导对心脏的生理功能与心力衰竭的关系，并综合介绍β 肾上腺素受体系统中一些关键蛋白的基因多态性与心力衰竭的易感性、预后及药物治疗效果的关联。最后，将探讨如何应用功能选择理论和基因组学发现新的心衰治疗靶点和新药，为新药研发和个体化医疗提供思路。

β-adrenergic receptors and heart failure

SONG Ying， WOO Yiu-ho Anthony， XIAO Rui-Ping*

(Beijing Key Laboratory of Cardiometabolic Molecular Medicine， Center for Life Sciences， Institute of Molecular Medicine， Peking University， Beijing 100871， China)

Abstract: Abstract: β-adrenergic receptors， particularly the β1 and the β2 subtypes， are the most important regulators of cardiac function. Here， we review the roles of β-adrenergic receptor subtype signaling in heart physiology and heart failure， and summarize how genetic polymorphism in some of the key proteins in the β-adrenergic system could affect susceptibility， prognosis and responses to drug treatment in human heart failure. Finally， we discuss how the concept of functional selectivity and a genomic approach could be applied in the discovery of new targets and new drugs for heart failure， and help set the stage for personalized medicine.