《生命科学》 2015, 27(2): 191-197

以髓磷脂相关抑制因子及其受体为靶点的脊髓损伤免疫治疗策略研究

陈开廷¹，王永堂²，舒亚海¹，肖　岚¹，鲁秀敏^1*

(¹ 重庆理工大学药学与生物工程学院，重庆 400054；² 第三军医大学大坪医院野战外科研究所创伤、烧伤与复合伤国家重点实验室，重庆 400042)

摘　要：摘　要：脊髓损伤(spinal cord injury， SCI) 往往导致患者下肢活动功能受限，甚至瘫痪，降低患者生活质量，且治愈率低。髓磷脂相关抑制因子(myelin associated inhibitors， MAIs) 是抑制受损中枢神经系统(central nervous system， CNS) 再生修复的一个重要因素。对MAIs 及其信号通路的干扰能有效逆转CNS 神经再生抑制信号，促进脊髓损伤后轴突的再生。MAIs 抑制轴突再生信号通路的发现及其深入研究为损伤脊髓的免疫治疗提供了充分的理论依据和研究靶点。将对抑制神经再生信号通路中MAIs 及其受体的生物学功能新进展以及以此为治疗靶点设计的脊髓损伤免疫治疗策略作一综述。

The study of immunotherapy strategies for spinal cord injury targeting myelin-associated inhibitors and their receptors

CHEN Kai-Ting¹， WANG Yong-Tang²， SHU Ya-Hai¹， XIAO Lan¹， LU Xiu-Min^1*

(¹ College of Pharmacy and Biological Engineering， Chongqing University of Technology， Chongqing 400054， China; ² State Key Laboratory of Trauma， Burns and Combined Injury， Institute of Surgery Research， Daping Hospital， Third Military Medical University， Chongqing 400042， China)

Abstract: Abstract: Spinal cord injury (SCI) often leads to lower limb function even paralysis with declined cure rate， and obviously reduces life quality of patients. Myelin-associated inhibitors (MAIs) play a pivotal role in inhibition of the regeneration of damaged central nervous system (CNS). Interferencing the function of MAIs or theirs signaling pathway is a promising method to overcome the inhibitory effects of MAIs in central nervous system， and enhances axonal regeneration after SCI. The roles of MAIs and downstream signaling pathway inhibiting axonal regeneration have been well investigated， which provides sufficient theoretical basis and target for SCI immunotherapy. The research of the biological function of MAIs and their receptors in inhibition of axonal regeneration and immunotherapy strategies for SCI is reviewed in this article.