《生命科学》 2015, 27(2): 168-173

促线粒体融合蛋白在线粒体融合和细胞凋亡中的作用

张　喆^1，2，孙　易^1，2，季　浏^1，2*

(¹ 华东师范大学体育与健康学院“青少年健康评价与运动干预”教育部重点实验室，上海 200241；² 华东师范大学体育与健康学院，上海 200241)

摘　要：摘　要：一直以来，线粒体动态变化都备受关注，这不仅关系到线粒体本身，也与细胞的整体状态密切相关。线粒体动态变化主要指线粒体的分裂和融合，该过程涉及一系列蛋白质。在线粒体融合中，目前研究得较深入的促线粒体融合蛋白主要有Mfn1、Mfn2 和OPA1。随着研究的深入，发现这3 种蛋白质不仅对于线粒体融合有重要作用，在细胞凋亡过程中也扮演着重要角色。现就Mfn1、Mfn2 和OPA1 的促线粒体融合作用及其与细胞凋亡的关系作详细阐述。

The dual roles of mitochondrial fusion proteins in mitochondrial fusion and apoptosis

ZHANG Zhe^1，2， SUN Yi^1，2， JI Liu^1，2*

(¹ Key Laboratory of Adolescent Health Assessment and Exercise Intervention， Ministry of Education， East China Normal University， Shanghai 200241， China; ² College of Physical Education & Health， East China Normal University， Shanghai 200241， China)

Abstract: Abstract: Mitochondrial dynamics has always been the focus of research， which is not only related to mitochondria themselves， but also is the key to maintaining normal cellular metabolism. Mitochondrial fission and fusion are two important mitochondrial events， in which a series of proteins are involved. Based on previous studies， we have come to the conclusion that mitochondrial fusion proteins not only play an important role in mitochondrial fusion， but also are vital to the changes during apoptosis. This article mainly focuses on Mfn1， Mfn2 and OPA1， and discusses their effects on mitochondrial fusion and apoptosis.